The Ajuba protein level was also higher in BC cell lines compared to normal breast epithelial cell line MCF-10A. Ajuba overexpression is correlated with advanced tumor-node-metastasis (TNM) stage, positive node status, and adverse patient outcomes.
The Ajuba expression level was elevated in breast cancer tissue compared with normal tissue. In the current study, we examined Ajuba protein levels in 93 invasive ductal carcinoma specimens by immunohistochemistry.
To date, its expression pattern and biological significance in breast cancers (BC) have not been fully investigated. The LIM protein Ajuba has been implicated in the development of human cancers.
